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KMID : 0377519750010010059
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Chung-Ang Journal of Medicine
1975 Volume.1 No. 1 p.59 ~ p.66
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A Study of Tumor Induction by Shope Papilloma Virus in Domestic Rabbits
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Im Choon-Bin
Yang Yong-Tae
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Abstract
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A study was made with Shope rabbit papilloma virus(RPV) on 1) papilloma induction and cancerous transformation in adult rabbits and 2) the progress of Shope papillomas induced in newborn rabbits, in order to confirm and extend the oncogenicity of RPV in adult rabbits and to observe the applicability of newborn rabbits for tumor induction by RPV. Virus inoculum was prepared from cottontail rabbits papilloma tissues stored in buffered glycerin (cottontail Shope T-730,1968.5.6.). Inoculation of RPV was made either by multiple puncture method into adult’s rabbit skin or by intradermal injection into newborn rabbit’s skin. Following RPV inoculation observations were made on the development of papilloma, cancerous transformation and spontaneous regression of induced papillomas. The results are summarized as follows: 1. Typical papillomas developed in adult rabbits at the site of RPV inoculation(10^-1,10^-2, and 10^-3) with a latent period of 2 to 5 weeks, and this confirmed a well-known stability of RPV during such a long period of storage in 50% buffered glycerin. 2. of 5 adult rabbits in which papillomas developed after RPV inoculation, cancerous transformation was observed in 2 rabbits approximately 1 year after virus inoculation at the sites where high concentration of RPV was inoculated. 3. RPV inoculation (10^-1) into newborn rabbit’s skin also resulted in the development of papillomas at the site of virus inoculation. The result of papilloma induction in newborn rabbits indicated that the latent periods were at least 1 to 2 weeks shorter and rather homogeneous than those in the adult rabbits, and that the papillomas appeared to persist longer than in adult rabbits.
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